TubeSpin® Bioreactors are designed for high-throughput screening, upstream process development, and optimization of suspension cell lines. They enable bioprocess development and scale-up studies using minimal sample volumes while maintaining maximum experimental parallelization.
Unlike conventional cell culture vessels, no additional harvesting or transfer step is required: cells can be directly centrifuged and further processed within the same vessel.
The TubeSpin® Bioreactor 87600 design is protected by an international design patent (WIPO/OMPI, 2023), highlighting its leading position in orbitally shaken single-use bioreactor technology.
System advantages over conventional culture vessels
- Higher throughput and parallelization than shake flasks or bottles
- Improved process transferability due to defined geometry
- Reduced handling steps through integrated workflow design
- Enhanced oxygen transfer compared to static culture systems
- Cost-efficient early-stage process development without bioreactor miniaturization
TubeSpin® Bioreactor 15
- Working volume: 1–10 ml
- Round or conical bottom
- Filter cap with variable openings (A–E) above PTFE gas membrane
- Spin: 15'500 x g
Ideal for early screening and clone selection
TubeSpin® Bioreactor 50
- Working volume: 1–35 ml
- Round or conical bottom
- Filter cap with variable openings (A–E) above PTFE gas membrane
- Spin: 15'500 x g
- Matching adapter plate for shakers available
Standard format for high-throughput screening
TubeSpin® Bioreactor 450
- Working volume: 1–300 ml
- Conical bottom
- 10-vent filter cap for optimized gas exchange
- Individually packaged interchangeable caps (solid / filter) available
- High oxygen transfer rates under orbital shaking conditions
- Directly applicable for scale-up–relevant studies
- Compatible with standard centrifuge rotors (up to 1 L format)
- Spin: 3'500 x g
- Matching adapter plates for shakers Kuhner and Infors available
Suitable for process development and early scale-up
TubeSpin® Bioreactor 600
- Working volume: 1–400 ml
- Conical bottom
- 10-vent filter cap for optimized gas exchange
- Individually packaged interchangeable caps (solid / filter) available
- High oxygen transfer rates under orbital shaking conditions
- Directly applicable for scale-up–relevant studies
- Compatible with standard centrifuge rotors (up to 1 L format)
- Spin: 3'500 x g
- Matching adapter plates for shakers Kuhner and Infors available
Validated for mid-scale production volumes
